论文部分内容阅读
目的研究曲美他嗪改善ST段抬高型急性心肌梗死的心功能疗效。方法入选200例ST段抬高型急性心肌梗死经过溶栓等再灌注治疗,病情稳定7～10天后行冠状动脉造影检查梗死相关动脉TIMI3级血流的患者,在常规治疗基础上随机分为治疗组和对照组(双盲)。对照组按照临床需要给予硝酸脂类、血管紧张素转化酶抑制剂(ACEI)、β受体阻滞剂、他汀类药物;治疗组在此基础上给予曲美他嗪20mg,3次/日,疗程8周。对比两组患者在临床活动耐量及心功能方面的变化,评价治疗效果。结果急性心肌梗死患者在常规治疗基础上加曲美他嗪后与对照组相比,心功能明显改善(P<0.01),6分钟步行实验距离明显延长(P<0.01),且该药有良好的耐受性和安全性。结论曲美他嗪能通过优化心肌能量代谢达到改善生活质量和延缓心力衰竭的作用,预示着能进一步降低死亡率,提高生存率。
Objective To study the effect of trimetazidine on cardiac function in patients with ST-elevation acute myocardial infarction. Methods A total of 200 ST-segment elevation acute myocardial infarction patients were treated with thrombolytic therapy and reperfusion therapy. The patients undergoing coronary artery angiography with TIMI grade 3 flow in infarction-related arteries after stable 7 to 10 days were randomly divided into treatment Groups and controls (double blind). In the control group, nitrets, ACE inhibitors, β-blockers and statins were given according to the clinical needs. The treatment group was given trimetazidine 20 mg on the basis of the above three times a day, Treatment for 8 weeks. The changes of clinical activity tolerance and cardiac function in two groups were compared to evaluate the therapeutic effect. Results In patients with acute myocardial infarction, trimetazidine was given on a routine basis with a significant improvement in cardiac function (P <0.01) and a 6-minute walk (P <0.01), and the drug was well Tolerance and safety. Conclusion Trimetazidine can improve the quality of life and delay heart failure by optimizing myocardial energy metabolism, which indicates that it can further reduce the mortality and improve the survival rate.