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目的观察氨茶碱和纳络酮治疗早产儿原发性呼吸暂停的临床效果。方法100例患儿随机分为2组,治疗组50例在使用氨茶硷的基础上加用纳络酮,对照组50例单用氨茶硷。结果治疗组和对照组患儿的呼吸暂停次数分别为(1.8±0.2)、(3.4±1.2)次/d,治疗组明显减少(P<0.01)。治疗组和对照组患儿的呼吸暂停时间分别为(18.9±3.1)、(23.2±2.51)s,治疗组明显缩短(P<0.01);治疗组和对照组患儿呼吸暂停时SPO2下降程度及心率减慢程度分别为(83.0±8.4)%和(75.7±5.2)%,(95.3±12.8)和(86.6±13.5)次/min,(均P<0.01。)治疗组总有效率92.6%,对照组总有效率68%(χ2=9.00,P<0.01)。结论氨茶碱和纳络酮联合治疗早产儿原发性呼吸暂停比单用氨茶碱效果好,值得临床推广。
Objective To observe the clinical effects of aminophylline and naloxone in the treatment of premature infants with primary apnea. Methods 100 cases of children were randomly divided into two groups, the treatment group of 50 patients on the basis of the use of aminophylline plus naloxone, the control group of 50 patients with aminophylline alone. Results The number of apnea in treatment group and control group were (1.8 ± 0.2) and (3.4 ± 1.2) times per day, respectively. The number of apnea was significantly decreased in treatment group and control group (P <0.01). The duration of apnea in treatment group and control group were (18.9 ± 3.1) and (23.2 ± 2.51) s respectively, and the treatment group was significantly shorter (P <0.01). The decrease of SPO2 and the decrease of SPO2 in the treatment group and the control group The heart rate slowed down to (83.0 ± 8.4)% and (75.7 ± 5.2)%, (95.3 ± 12.8) and 86.6 ± 13.5 times / min respectively (all P 0.01) .The total effective rate was 92.6% The total effective rate of the control group was 68% (χ2 = 9.00, P <0.01). Conclusion Aminophylline and naloxone combined treatment of premature children with primary apnea than aminophylline effective, worthy of clinical promotion.