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目的观察生长抑素联合乌司他丁治疗急性胰腺炎患者的临床效果。方法选取医院就诊的急性胰腺炎患者98例为研究对象,根据给药方式的不同分为对照组和观察组,每组49例。患者均实施静脉补液、镇静镇痛、营养支持等常规治疗,对照组给予生长抑素治疗,观察组给予生长抑素联合乌司他丁治疗。观察比较2组患者生化指标、临床疗效和并发症发生率。结果治疗后,2组脂肪酶、白细胞数、TNF-α和IL-6数值均降低,且观察组较对照组降低更明显(P<0.01);观察组总有效率为95.9%,高于对照组的77.6%(P<0.01);观察组并发症发生率为4.1%,低于对照组的18.4%(P<0.01)。结论在急性胰腺炎的临床治疗中,生长抑素联合乌司他丁联合用药可有效缓解患者的临床症状,提高治疗总有效率,降低并发症发生率,临床效果较好。
Objective To observe the clinical effect of somatostatin combined with ulinastatin in the treatment of acute pancreatitis. Methods A total of 98 patients with acute pancreatitis were selected as study subjects and divided into control group and observation group according to different administration modes, with 49 cases in each group. All patients underwent routine therapy such as intravenous rehydration, sedation and analgesia, nutritional support, and the control group received somatostatin and the observation group received somatostatin and ulinastatin. The biochemical indexes, clinical curative effects and complication rates in two groups were observed and compared. Results After treatment, the numbers of lipase, leucocyte, TNF-α and IL-6 in the two groups decreased, and the observation group was more obvious than the control group (P <0.01). The total effective rate in the observation group was 95.9% (P <0.01). The complication rate in observation group was 4.1%, which was lower than that in control group (18.4%, P <0.01). Conclusion In the clinical treatment of acute pancreatitis, combination of somatostatin and ulinastatin can effectively relieve the clinical symptoms of patients, improve the total effective rate and reduce the incidence of complications, the clinical effect is better.