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本研究表明，Ｔ淋巴细胞中ｃＡＭＰ和ｃＧＭＰ含量具有昼夜节律，表现其峰值相分别位于－１８５°（１２∶２０）和－１８°（１∶１２），中值相差３．１２倍。氯氰菊酯染毒后，ｃＡＭＰ含量升高而ｃＧＭＰ含量降低，ｃＡＭＰ／ｃＧＭＰ比值增大。但这些变化只发生在部分昼夜时点（０４∶００，０８∶００，２０∶００和２４∶００），呈现明显的时间－效应。经在１／３ＬＤ５０和１／３０ＬＤ５０两种剂量染毒后，ｃＡＭＰ和ｃＧＭＰ含量的昼夜节律均消失，表明氯氰菊酯可破坏生理性节律系统。由于ｃＡＭＰ与ｃＧＭＰ节律的峰值和谷值相之间表现相互倒置的关系，使氯氰菊酯对Ｔ淋巴细胞的毒效应出现相应的时相性差异。这些结果提示，氯氰菊酯通过改变淋巴细胞内ｃＡＭＰ和ｃＧＭＰ的含量以及破坏其生理性昼夜节律，可导致免疫功能的降低。
The present study showed that circadian rhythms of cAMP and cGMP in T lymphocytes were peaked at -185 ° (12:20) and -18 ° (1:12), respectively, with a median difference of 3.12-fold. Cypermethrin exposure, cAMP content increased cGMP content decreased, cAMP / cGMP ratio increased. However, these changes occurred only at some day and night time points (04:00, 08:00, 20:00 and 24:00), showing a clear time-effect. The circadian rhythms of cAMP and cGMP levels disappeared after exposure to both 1 / 3LD50 and 1 / 30LD50 doses, indicating that cypermethrin destroys the circadian rhythmic system. Due to the reciprocal relationship between cAMP and cGMP rhythm peak and trough phase, the toxic effects of cypermethrin on T lymphocytes appeared corresponding phase difference. These results suggest that cypermethrin can lead to a decrease in immune function by altering the content of cAMP and cGMP in lymphocytes and disrupting their circadian rhythms.