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目的探讨补充维生素D对急性腹泻患儿血清25-羟维生素D[25-hydroxvitamin D,25(OH)D]与炎症因子水平的影响。方法选取2013年12月—2016年12月扬州大学附属医院确诊治疗的急性腹泻患儿100例,依据治疗方法分为A组和B组,每组50例,A组给予常规对症治疗,B组在A组常规对症治疗的基础上给予维生素D。结果 A组和B组治疗有效率分别为80.00%和96.00%,B组明显高于A组,差异有统计学意义(P<0.05)。A组和B组呕吐、大便次数和性状复常时间分别为(4.45±0.54)d和(3.73±0.51)d、(4.75±0.57)d和(3.82±0.53)d、(2.33±0.36)d和(1.92±0.30)d,B组明显低于A组,差异有统计学意义(P<0.05),但两组不良反应发生率,差异无统计学意义(P>0.05);B组治疗后血清25(OH)D水平明显高于A组,B组血清白细胞介素6(interleukin 6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平明显低于A组,B组治疗后上述指标变化值明显高于A组,差异有统计学意义(P<0.05)。结论补充维生素D治疗可有效提高急性腹泻患儿的治疗疗效,其可能与改善机体25(OH)D水平和炎症状态有关,且具有良好的安全性。
Objective To investigate the effect of vitamin D supplementation on the serum 25-hydroxyvitamin D (25 (OH) D] and inflammatory cytokines in children with acute diarrhea. Methods From December 2013 to December 2016, 100 children with acute diarrhea diagnosed and treated in the Affiliated Hospital of Yangzhou University were divided into group A and group B according to the treatment method, 50 cases in each group. Group A received conventional symptomatic treatment and group B A group of conventional symptomatic treatment based on the administration of vitamin D. Results The effective rates of A group and B group were 80.00% and 96.00%, respectively. The B group was significantly higher than that of A group (P <0.05). Vomiting, stool frequency and trait recovery time in group A and group B were (4.45 ± 0.54) d and (3.73 ± 0.51) days, (4.75 ± 0.57) days and (3.82 ± 0.53) days and (2.33 ± 0.36) days respectively (1.92 ± 0.30) d in group B, which were significantly lower in group B than in group A (P <0.05), but there was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05) Serum levels of 25 (OH) D were significantly higher in group A than those in group A. Levels of serum interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) in group B were significantly lower than those in group A Group B, B group after treatment, the above index changes were significantly higher than the A group, the difference was statistically significant (P <0.05). Conclusions Vitamin D treatment can effectively improve the therapeutic efficacy of children with acute diarrhea, which may be related to the improvement of the level of 25 (OH) D and inflammatory state, and has good safety.