癫痫在临床比较常见,严重影响患者身心健康,影响了家庭的幸福。特别是难治性癫痫,由于发作反反复复,伴有不同的临床和脑电图的表现[1]。癫痫病人中有约25%～30%治疗效果十分差,因此,寻找有效、简便的治疗方法是摆在神经科医生的重要课题,对难治性癫痫的病理状况进行研究是寻找有效治疗方法的重要途径,为此,笔者收集有关文献并结合工作实际对难治性癫痫的病理研究进展进行阐述。 Epilepsy is more common in clinical practice, seriously affecting the patient’s physical and mental health, affecting the family’s happiness. Especially refractory epilepsy, due to seizures repeatedly, accompanied by different clinical and electroencephalographic performance [1]. About 25% to 30% of patients with epilepsy have very poor therapeutic effects. Therefore, looking for an effective and simple treatment is an important issue for neurologists. Studying the pathological conditions of refractory epilepsy is to find effective treatments Therefore, I collected the relevant literature and combined with the actual work on the pathological progress of refractory epilepsy.