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目的观察矽尘接触者和矽肺患者血清中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平,探讨SOD、GSH-Px在矽肺发生发展中的作用。方法采用酶联免疫吸附法和化学比色法对100名不接触粉尘的对照人群,200名接触矽尘1 a以上的接尘工人,32名矽尘作业观察对象及130例矽肺患者,检测其血清SOD、GSH-Px水平。结果接尘组和矽肺组SOD水平明显低于正常对照组,矽肺组SOD水平与对照组比较,差异有统计学意义(P<0.05);GSH-Px水平矽肺组明显高于正常对照组和接尘组,差异有统计学意义(P<0.01),且矽肺期别愈高GSH-Px亦随之升高。结论血清中SOD、GSH-Px水平与矽肺发病有明显相关关系,并与矽肺的严重程度也有关,提示机体氧化和抗氧化系统的失衡与矽肺的发生发展有关。
Objective To observe the levels of serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in silicosis and silicosis patients and explore the role of SOD and GSH-Px in the development of silicosis. Methods 100 control subjects exposed to dust, 200 exposure workers exposed to silica dust for more than 1 year, 32 objects exposed to silica dust and 130 patients with silicosis were detected by enzyme-linked immunosorbent assay and chemical colorimetry. Serum SOD, GSH-Px levels. Results The level of SOD in the dust-receiving group and the silicosis group was significantly lower than that in the normal control group. The level of SOD in the silicosis group was significantly higher than that in the control group (P <0.05). The level of GSH-Px in the silicosis group was significantly higher than that in the normal control group Dust group, the difference was statistically significant (P <0.01), and the higher the silicosis stage GSH-Px also increased. Conclusion Serum levels of SOD and GSH-Px have a significant correlation with the incidence of silicosis, and are also related to the severity of silicosis. It indicates that the imbalance of oxidative and antioxidant systems in the body is related to the occurrence and development of silicosis.