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选择４９例膀胱移行细胞癌标本，１０例正常膀胱组织标本。应用免疫组化法观察多药耐药基因产物Ｐ－糖蛋白（Ｐ－ｇｐ）在膀胱肿瘤组织中的表达及临床意义，结果显示：（１）正常膀胱组织中Ｐ－ｇｐ无表达，膀胱肿瘤组织中Ｐ－ｇｐ阳性表达率为７１．４％：（２）Ｐ－ｇｐ阳性表达的膀胱肿瘤复发率为５１．６％：（３）在死亡组中Ｐ－ｇｐ阳性表达＊率为８３．３％。表明膀胱肿瘤中Ｐ－ｇｐ的高阳性表达提示其复发率高，预后差，可作为临床上判定膀胱肿瘤患者预后情况及选择治疗方案的一个参考指标。
Select 49 cases of bladder transitional cell carcinoma specimens, 10 cases of normal bladder tissue specimens. Immunohistochemistry was used to observe the expression of P-glycoprotein (P-gp) in bladder tumor and its clinical significance. The results showed that: (1) P-gp was not expressed in normal bladder tissue, The positive expression rate of P-gp in the tissue was 71.4% (2) The recurrence rate of bladder tumor with P-gp expression was 51.6% (3) The positive rate of P-gp expression in the death group was 83% .3%. The high positive expression of P-gp in bladder tumors suggests that the recurrence rate is high, the prognosis is poor, which can be used as a reference index to determine the prognosis of patients with bladder cancer clinically and to choose the treatment regimen.