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目的：分析影响小脑髓母细胞瘤（ＭＢ）预后的因素。方法：对９９例小脑ＭＢ进行临床病理形态学观察及ＰＣＮＡ、Ｓｙｎ、ＮＦＰ和ＧＦＡＰ免疫组化ＡＢＣ法标记。采用单因素ｌｏｇ－ｒａｎｋ检验及多因素Ｃｏｘ风险回归模型进行预后分析。结果：单因素分析显示年龄＞１８岁（Ｐ＜０．０５）、促纤维增生型ＭＢ（Ｐ＜０．０５）、肿瘤无灶状坏死（Ｐ＜０．００１）、ＰＣＮＡ标记指数低（Ｐ＜０．０５）及术后进行放射治疗（Ｐ＜０．００１）的病人预后好。多因素分析显示术后未进行放疗（Ｐ＜０．００１）、肿瘤有灶状坏死（Ｐ＜０．００１）、ＰＣＮＡ标记指数高（Ｐ＜０．０５）、经典型ＭＢ（Ｐ＜０．０５）、年龄＜１８岁（Ｐ＜０．０５）及分裂象计数高（Ｐ＜０．０５）是６个影响ＭＢ预后的危险因素。结论：年龄、组织类型、细胞增殖活性、肿瘤灶状坏死及术后放射治疗是影响ＭＢ预后的重要因素
Objective: To analyze the factors affecting the prognosis of cerebellar medulloblastoma (MB). Methods: The clinical pathomorphology of 99 cases of cerebellum and the immunohistochemical ABC, PCNA, Syn, NFP and GFAP markers were detected. One-factor log-rank test and multivariate Cox risk regression model were used for prognostic analysis. Results: The results of univariate analysis showed that the age of> 18 years (P <0.05), fibroblast hyperplasia MB (P <0.05), tumor necrosis (P <0.001) <0.05) and postoperative radiotherapy (P <0.001) patients with good prognosis. Multivariate analysis showed that there was no postoperative radiotherapy (P <0.001), tumor necrosis (P <0.001), PCNA labeling index (P <0.05), and classic MB (P < 05), age <18 years (P <0.05) and meiosis counts (P <0.05) were the 6 risk factors for prognosis of MB. Conclusion: Age, type of tissue, cell proliferative activity, tumor necrosis and postoperative radiotherapy are the important factors affecting the prognosis of MB