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海藻硫酸多糖(SP)是一种从褐藻中提取的天然硫酸酯化多糖,它具有多种药理作用。国内外对其辐射防护作用的研究仅限于整体水平。该课题就动物整体、细胞及分子水平对SP的辐射防护作用及其可能机理进行了研究:(1)以γ射线照射小鼠为模型,观察了SP对受照小鼠的外周血恢复及30d存活率的影响;(2)以造血因子依赖细胞株(NFS-60及TF-
Seaweed sulfate polysaccharide (SP) is a natural sulfated polysaccharide extracted from brown algae, which has a variety of pharmacological effects. The research on radiation protection at home and abroad is limited to the overall level. This topic studies the radiation protection and possible mechanism of SP on the whole animal, cell and molecular level: (1) Irradiated mice with γ-irradiation as a model, observes the recovery of peripheral blood from irradiated mice by SP and 30 days Effects of survival rate; (2) Hematopoietic factor-dependent cell lines (NFS-60 and TF-