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主要由白色脂肪组织产生的瘦素(leptin)可通过对下丘脑神经元的作用来调节摄食行为。能量代谢和生殖内分泌功能。其不仅对女性营养和生殖平衡有重要作用,而且在男性生殖中也具有重要作用,leptin能作用于下丘脑ARC-VMN调节生殖,但其刺激GnRH分泌效应具有两重性:长期高leptin血症可引起中枢对leptin信号传递的敏感性下调。leptin对ARC的调节主要通过神经肽Y(NPY)、可卡因-安非他明-调节转录物(CART)和Galanin样多肽(GALP)等多肽发挥。睾丸中也存在leptin受体,leptin对hCG诱导的睾丸培养组织睾酮分泌具有明显的抑制作用且存在剂量相关性,其对雄激素合成的影响位点在孕激素下游 睾酮可能是调节leptin水平的重要因子,它与血清leptin呈负相关,而这种负相关依赖于IGF结合蛋白-1(IGFBP-1)的作用
Leptin, which is produced mainly by white adipose tissue, regulates feeding behavior by acting on hypothalamic neurons. Energy metabolism and reproductive endocrine function. It not only plays an important role in the nutrition and reproductive balance of women, but also plays an important role in male reproduction. Leptin acts on hypothalamus ARC-VMN to regulate reproduction, but its stimulation of GnRH secretion has duality: long-term high leptinmia can cause Central nervous system on leptin signaling sensitivity down. The regulation of ARC by leptin is mainly exerted by peptides such as neuropeptide Y (NPY), cocaine-amphetamine-regulated transcript (CART) and Galanin-like polypeptide (GALP) Leptin receptor also exists in testes. Leptin has a significant inhibitory effect on testosterone secretion induced by hCG in testis culture and there is a dose-dependent effect. The effect of leptin on testosterone in the testosterone downstream of progesterone may play an important role in the regulation of leptin level Factor, which is negatively correlated with serum leptin, and this negative correlation is dependent on the effect of IGF-binding protein-1 (IGFBP-1)