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目的对比腹膜透析、血液透析对尿毒症患者钙磷代谢的影响,指导两种透析的应用。方法 80例尿毒症患者,采用随机数字表法分为腹膜组(给予腹膜透析)及血液组(给予血液透析),各40例。对比两组患者的高水平甲状旁腺激素(iPTH)、校正钙、血磷、钙磷乘积水平及不良反应发生情况。结果腹膜组iPTH水平(222.45±249.16)pg/ml、血磷水平(1.31±0.43)mmol/L低于血液组(315.42±280.43)pg/ml、(1.87±1.13)mmol/L,差异均有统计学意义(P<0.05)。两组校正钙、钙磷乘积水平对比,差异均无统计学意义(P>0.05)。腹膜组不良反应发生率为15.0%,血液组不良反应发生率为25.0%,对比差异无统计学意义(χ~2=1.25,P>0.05)。结论腹膜透析相较于血液透析,血磷、PTH清除效果更好。
Objective To compare the effects of peritoneal dialysis and hemodialysis on calcium and phosphorus metabolism in patients with uremia and to guide the application of the two kinds of dialysis. Methods Eighty patients with uremia were divided into peritoneal dialysis group and hematological group by hemodialysis (randomized numerical table), 40 cases in each group. Compare the high level of parathyroid hormone (iPTH) between the two groups, and correct the level of calcium, phosphorus, calcium and phosphorus products and the incidence of adverse reactions. Results The levels of iPTH in peritoneum group (222.45 ± 249.16) pg / ml and phosphorus level (1.31 ± 0.43) mmol / L were lower than those in the blood group (315.42 ± 280.43 pg / ml, 1.87 ± 1.13 mmol / L, Statistical significance (P <0.05). There was no significant difference between the two groups in corrected calcium and calcium phosphate product levels (P> 0.05). The incidence of adverse reactions in the peritoneal group was 15.0%, and the incidence of adverse reactions in the blood group was 25.0%. There was no significant difference between the two groups (χ ~ 2 = 1.25, P> 0.05). Conclusion Peritoneal dialysis compared with hemodialysis, phosphorus, PTH removal better.