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目的 探讨异烟肼预防食管良性狭窄的作用。方法 分动物实验及临床应用两部分 ,动物实验采用家犬 2 0只 ,分为 3组 ,按Davis动物模型致伤为深II度食管腐蚀伤 ,采用异烟肼治疗 ;临床应用系对 2 6例食管良性狭窄患者采取扩张术后异烟肼治疗以预防食管再狭窄。结果 动物实验组显示异烟肼具有显著抑制食管腐蚀伤后胶原合成的作用 ,治疗组食管管腔显著大于对照组 (P <0 .0 1) ,食管顺应性明显优于对照组 (P <0 .0 1)。临床病例除 2例失访外其余均获得满意疗效。结论 异烟肼能够防治食管良性狭窄 ,在临床工作中有一定的推广价值
Objective To investigate the role of isoniazid in preventing esophageal stricture. Methods Animal experiments and clinical application of two parts, animal experiments using domestic dogs 20, divided into 3 groups, according to Davis animal model of injury for deep II degree esophageal erosion, the use of isoniazid treatment; clinical application of 2 6 In patients with benign esophageal stenosis, isoniazid after dilation was used to prevent esophageal restenosis. Results The experimental group showed that isoniazid significantly inhibited collagen synthesis after esophageal erosion. The esophageal lumen of the treated group was significantly larger than that of the control group (P <0.01), and the esophageal compliance was significantly better than that of the control group (P <0 .0 1). In addition to 2 cases of clinical cases were lost to the rest were satisfactory results. Conclusion Isoniazid can prevent benign esophageal stenosis and has certain promotion value in clinical work