钒在大鼠妊娠期间经胎盘转运的研究

来源 :华西医科大学学报 | 被引量 : 0次 | 上传用户:huanghuimin1224
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作者用极谱法测定了妊娠大鼠经腹腔注射V_2O_5后母鼠血、胎盘、羊水和胎鼠组织中的钒含量。结果表明,钒在妊娠的胚胎期和胎儿期均可透过胎盘进入胚胎/胎鼠体内,但胎盘对钒有一定屏障作用。给药后4小时胎鼠组织中钒含量达最高,120小时仍维持相当浓度,表明胎鼠对钒有蓄积作用。 The author used polarography to determine the content of vanadium in the blood, placenta, amniotic fluid and fetal rat tissue of pregnant rats after intraperitoneal injection of V 2 O 5. The results showed that vanadium can enter the embryo / fetal rat through the placenta during the embryonic and fetal stages of pregnancy, but the placenta has a certain barrier effect on vanadium. 4 hours after administration of vanadium in fetal rat tissue up to the highest level, 120 hours still maintained a considerable concentration, indicating that fetal rats have a role in the accumulation of vanadium.
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