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目的回顾性分析天津地区健康体检人群男女性尿酸(UA)水平变化趋势及影响因素,为个体化健康指导意见提供理论依据。方法选择2014年在天津市肿瘤医院预防体检中心体检并符合标准的45 229名健康体检者为研究对象,检测血清UA、甘油三酯(TG)、总胆固醇(TC)、空腹血糖(FPG),用SPSS 19.0统计软件包进行t检验、多元线性回归和多因素logistic回归分析,趋势判断采用Cox-Staut趋势存在性检验。结果男性UA水平随着年龄的增加而降低,女性UA水平随着年龄的增加而升高,差异均有统计学意义(P<0.01)。多元线性回归分析显示,男性UA与TC、TG呈正相关,与年龄和FPG呈负相关(r值分别为0.100、0.269、-0.139和-0.110,P<0.01);女性UA与TC、TG和年龄均呈正相关(r值分别为0.208、0.346和0.191,P<0.01)。不同性别、年龄HUA检出率与UA水平变化趋势一致,男性HUA检出率从40岁开始出现显著降低,而高FPG检出率则显著升高。logistic多因素回归分析显示,TC>5.71 mmol/L、TG>1.81 mmol/L为男性HUA的危险因素(OR值分别为1.288、2.553),FPG≥5.87 mmol/L为男性HUA的保护因素(OR=0.766);TC>5.71 mmol/L、TG>1.53 mmol/L、FPG≥5.53 mmol/L均是女性HUA的危险因素(OR值分别为1.347、3.969和1.659)。结论年轻男性以及≥50岁女性应积极关注UA水平,高UA水平与血脂异常密切相关,男性UA水平及HUA检出率随年龄的变化趋势与FPG有关。
Objective To retrospectively analyze the trends and influencing factors of uric acid (UA) levels in male and female Uygur people in Tianjin and provide a theoretical basis for individualized health guidance. Methods A total of 45 229 healthy physical examinations were performed at Tianjin Cancer Hospital Preventive Medical Examination Center in 2014. The serum levels of UA, triglyceride (TG), total cholesterol (TC), fasting plasma glucose (FPG) SPSS 19.0 statistical package was used for t-test, multivariate linear regression and multivariate logistic regression analysis, trend determination using Cox-Staut trend of existence test. Results Male UA levels decreased with increasing age, female UA levels increased with age, the differences were statistically significant (P <0.01). Multivariate linear regression analysis showed that male UA was positively correlated with TC, TG and negatively correlated with age and FPG (r = 0.100, 0.269, -0.139 and -0.110 respectively, P <0.01); female UA, TC, TG and age (R values were 0.208, 0.346 and 0.191 respectively, P <0.01). The prevalence of HUA in different genders and ages was consistent with that of UA. The prevalence of HUA in men was significantly lower from 40 years old, while the detection rate of high FPG was significantly higher. Logistic multivariate regression analysis showed that the risk factors for HUA were 1.87 and 2.553 respectively for TC> 5.71 mmol / L and TG> 1.81 mmol / L for FPG and 5.87 mmol / L as the protective factor for HUA in men = 0.766). TC> 5.71 mmol / L, TG> 1.53 mmol / L and FPG≥5.53 mmol / L were all risk factors for women with HUA (OR = 1.347, 3.696 and 1.659, respectively). Conclusion Young men and women over 50 years old should pay close attention to the level of UA. High UA level is closely related to dyslipidemia. The trend of UA level and detection rate of HUA in men with age is related to FPG.