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目的:研究SSF对小鼠脑缺氧的保护作用。方法:50、100、200 mg/kg 的SSF连续ig小鼠14d,各组小鼠分别ip KCN (10 mg/kg)或结扎带迷走神经的双侧颈总动脉,记录小鼠ip KCN和结扎带迷走神经双侧颈总动脉后存活时间,脑复康为对照药。结果:50、100、200 mg/kg SSF组小鼠ip KCN后存活时间比盐水对照组分别延长37.65%、95.67%和38.55%;100 mg/kg SSF作用优于脑复康(200 mg/kg)。3个剂量组小鼠结扎双侧颈总动脉存活时间分别是盐水对照组的1.84、1.94、2.29倍;100 mg/kg SSF作用与200 mg/kg脑复康作用相当。结论:SSF对小鼠脑缺氧有保护作用。
Objective: To study the protective effect of SSF on cerebral hypoxia in mice. METHODS: 50, 100, 200 mg/kg SSF mice were consecutively ig for 14 days. Each group of mice received ip KCN (10 mg/kg) or ligated common carotid artery with vagus nerve. Mouse ip KCN and ligation band were recorded. The survival time of bilateral common carotid arteries of vagus nerve was controlled by Naofukang. RESULTS: The survival time of ip KCN in 50, 100, 200 mg/kg SSF mice was 37.65%, 95.67% and 38.55% longer than that of saline control group, respectively; the effect of 100 mg/kg SSF was better than that of Naoki Kang (200 mg/kg). ). The survival time of bilateral common carotid arteries in the three dose groups was 1.84, 1.94 and 2.29 times of the saline control group, respectively; the effect of 100 mg/kg SSF was similar to that of 200 mg/kg brain rehabilitation. Conclusion: SSF has a protective effect on mouse brain hypoxia.