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目的:探讨血清免疫球蛋白IgM和C-反应蛋白联合测定在新生儿早期细菌感染诊断中的意义。方法:采用免疫比浊法测定100例发生细菌感染的新生儿(感染组)、50例非感染病症新生儿(未感染组)的血清IgM和CRP水平。结果:感染组CRP水平与非感染组比较差异无显著性(P>0.05);感染组IgM水平与非感染组比较差异有显著性(P<0.05)。CRP对感染性疾病的诊断灵敏度Se为95.0%,特异度Sp为58.0%,准确度Ac为82.67%;IgM测定,灵敏度为88.0%,特异度为82.0%,准确度为86.0%;两者联合测定,灵敏度SeCs为86.67%,特异度SpCs为93.33%。结论:血清IgM与CRP联合测定可作为诊断新生儿早期细菌感染的指标。
Objective: To investigate the significance of serum immunoglobulin IgM and C-reactive protein in the diagnosis of early neonatal bacterial infection. Methods: Serum IgM and CRP levels were measured in 100 newborns with bacterial infection (infection group) and 50 non-infected newborns (uninfected group) by immunoturbidimetry. Results: The level of CRP in infection group was not significantly different from that in non-infected group (P> 0.05). The level of IgM in infection group was significantly lower than that in non-infected group (P <0.05). The diagnostic sensitivity of CRP to infectious diseases was 95.0% for Se, 58.0% for Sp, and 82.67% for Ac; the sensitivity and specificity of CRM were 88.0%, 82.0% and 86.0%, respectively The sensitivity and specificity of SeCs were 86.67% and 93.33% respectively. Conclusion: The combined determination of serum IgM and CRP can be used as an indicator of early neonatal bacterial infection.