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目的观察克拉霉素与雷尼替丁铋盐联合应用治疗消化性溃疡幽门螺杆菌阳性患者的临床效果。方法选择2012年2月-2014年9月幽门螺杆菌阳性的消化性溃疡患者70例,随机分为观察组和对照组各35例,观察组使用克拉霉素联合雷尼替丁铋盐治疗,对照组仅单纯克拉霉素治疗。分析治疗后患者幽门螺杆菌的根除率、疗效及复发率。结果观察组的总有效率、幽门螺杆菌根除率及复发率均低于对照组,观察组患者腹痛、嗳气、腹胀缓解时间均短于对照组,差异均具有统计学意义(P<0.05)。结论克拉霉素联合雷尼替丁铋盐治疗方法对消化性溃疡患者的幽门螺杆菌根除率高,可提倡应用于临床。
Objective To observe the clinical effect of combined use of clarithromycin and ranitidine bismuth in the treatment of patients with peptic ulcer-positive Helicobacter pylori. Methods Seventy patients with Helicobacter pylori-positive peptic ulcer were selected from February 2012 to September 2014. They were randomly divided into observation group and control group with 35 cases each. The observation group was treated with clarithromycin combined with ranitidine bismuth salt, Control group only simple clarithromycin treatment. Analysis of treatment of patients with Helicobacter pylori eradication rate, efficacy and recurrence rate. Results The total effective rate, the eradication rate of Helicobacter pylori and the recurrence rate of the observation group were lower than those of the control group. The patients in the observation group were shorter than the control group in abdominal pain, belching and bloating duration, the differences were statistically significant (P <0.05). Conclusion Clarithromycin combined with ranitidine bismuth salt treatment of peptic ulcer patients with high eradication rate of Helicobacter pylori can be used in clinical practice.