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目的：探讨１Ｈ－ＭＲＳ在颞叶癫 （ＴＬＥ）定侧诊断（ＬＤ）中的价值。材料和方法：２０例手术和病理证实的顽固性颞叶癫 患者和１５例健康志愿者为研究对象。患者术前采用 １～７天的视频脑电连续监护或（和）颅内电极脑电图（ＥＥＧ）行定侧诊断。采用ＧＥ１．５Ｔ Ｓｉｇｎｓ Ｈｏｒｉｚｏｎ ＬＸ超导磁共振机，作双侧颞叶内侧的１Ｈ－ＭＲＳ，感兴趣区大小为２ｃｍ ×２ｃｍ × ２ｃｍ。将正常对照组ＮＡＡ／（Ｃｒ＋Ｃｈｏ）比值的９５％可信区间的下限值和双侧ＮＡＡ／（Ｃｒ＋Ｃｈｏ）比值差别的最大值定为１Ｈ－ＭＲＳ ＴＬＥ ＬＤ的标准。分析１Ｈ－ＭＲＳ作为ＴＬＥ ＬＤ的价值，并与ＥＥＧ、病理、 ＰＥＴ及ＭＲＩ所见相对照。结果：正常对照组ＮＡＡ／（Ｃｒ＋Ｃｈｏ）比值平均为０．８１±０．１３（０．７０～１．０５）；双侧ＮＡＡ／（Ｃｒ＋Ｃｈｏ）比值的差别平均为５％±２％（１％～１０％）。以ＮＡＡ／（Ｃｒ＋Ｃｈｏ）＜０．６８和双侧ＮＡＡ／（Ｃｒ＋Ｃｈｏ）比值的差别＞７％作为ＴＬＥ ＬＤ的标准。手术切除的颞叶均有病理改变，术后随访２０例均有疗效，表明ＥＥＧ定侧全部正确。２０例中的１６例（８０％）１Ｈ－ＭＲＳＬＤ与ＥＥＧ相符，１例不符，另外３例１Ｈ－
Objective: To investigate the value of 1H-MRS in the diagnosis of temporal lobe epilepsy (TLE). MATERIALS AND METHODS: Twenty patients with refractory temporal lobe epilepsy confirmed by surgery and pathology and 15 healthy volunteers were enrolled in this study. Patients preoperatively with 1 ~ 7 days of video EEG continuous monitoring or (and) intracranial electrode electroencephalogram (EEG) line side diagnosis. The 1H MRS of the medial temporal lobe was performed using the GE1.5T Signs Horizon LX superconducting magnetic resonance scanner. The size of the region of interest was 2 cm × 2 cm × 2 cm. The maximum value of the difference between the 95% confidence interval of NAA / (Cr + Cho) ratio and the ratio of bilateral NAA / (Cr + Cho) ratio in normal control group was taken as the standard of 1H-MRS TLE LD. The value of 1H-MRS as a TLE LD was analyzed and compared with that seen with EEG, pathology, PET, and MRI. Results: The NAA / (Cr + Cho) ratio was 0.81 ± 0.13 (0.70 ~ 1.05) in the normal control group and 5% ± 2% (1%) in the bilateral NAA / (Cr + Cho) ~ 10%). The standard of TLE LD was taken as the difference of NAA / (Cr + Cho) <0.68 and bilateral NAA / (Cr + Cho) ratio> 7%. Surgical resection of the temporal lobe pathological changes were followed up in 20 cases were curative effect, indicating EEG set side correct. Of the 20 cases, 16 (80%) 1H-MRSLD was consistent with EEG, 1 case did not and 1 case of 1H-