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目的探讨治疗药物监测手段支持围生期孕妇应用亚胺培南/西司他丁钠治疗的作用。方法 1名孕29周患者因宫内感染使用亚胺培南/西司他丁钠进行抗感染治疗,为明确药物使用的安全性,临床药师通过治疗药物监测手段,协助临床科室进行围生期抗感染治疗。结果与结论对母体静脉血及胎儿脐带血进行血药浓度监测发现,母体及胎儿的血药浓度均在安全范围,通过随访,母婴均恢复良好出院。临床药师为临床特殊患者进行治疗药物监测,为围生期使用美国食品药品监管理局妊娠分级C级的抗菌药物积累了应用经验和药学监护方法。
Objective To investigate the effect of therapeutic drug monitoring on imipenem / cilastatin in perinatal pregnant women. Methods One pregnant 29week patient was treated with imipenem / cilastatin sodium for intrauterine infection. In order to clarify the safety of drug use, clinical pharmacists assisted the clinical departments in perinatal treatment by means of drug monitoring Anti-infective treatment. Results and Conclusion The plasma concentration of maternal venous blood and fetus cord blood was monitored. The plasma concentrations of maternal and fetus were in the safe range. After follow-up, both mother and child recovered well. Clinical pharmacists for the treatment of patients with special clinical drug monitoring, perinatal use of the US Food and Drug Administration pregnancy grading C-class antimicrobial drugs has accumulated experience and application of pharmacy monitoring methods.