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目的比较曲美他嗪和美托洛尔对伴发2型糖尿病的稳定型心绞痛患者的疗效差异。方法采用交叉设计,设曲美他嗪-美托洛尔(AB组)和美托洛尔-曲美他嗪(BA组)2种服药顺序组,曲美他嗪20mg,tid,8周,美托洛尔12.5mg,bid,8周,2种药物服用间期1周。分别记录2组用药前及用药8周心绞痛发作次数、硝酸甘油用量、运动平板心电图。结果综合交叉试验结果,心绞痛发作次数、硝酸甘油用量、ST段压低1mm的时间、ST段压低最大幅度4个参数显示曲美他嗪与美托洛尔同样减轻症状发作,提高运动耐量,两者疗效差异无统计学意义。结论曲美他嗪和美托洛尔均对伴发2型糖尿病的稳定型心绞痛患者有效。
Objective To compare the efficacy of trimetazidine and metoprolol in patients with stable angina who have type 2 diabetes mellitus. Methods A crossover design was adopted. Two medication groups, trimetazidine-metoprolol (AB group) and metoprolol-trimetazidine (BA group) Propranolol 12.5mg, bid, 8 weeks, two kinds of drugs taking period of 1 week. The number of episodes of angina pectoris, the amount of nitroglycerin and treadmill electrocardiogram were recorded before treatment and 8 weeks respectively. Results The results of comprehensive crossover test, the number of angina attacks, the amount of nitroglycerin, the time of depression of ST segment by 1 mm and the maximum amplitude of ST segment depression showed that trimetazidine and metoprolol also alleviated the symptoms and increased exercise tolerance, both No significant difference in efficacy. Conclusion Both trimetazidine and metoprolol are effective in patients with stable angina with type 2 diabetes mellitus.