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目的探讨慢性病毒性肝炎肿瘤相关抗原与肝纤维化指标的关系。方法对51例慢性乙型肝炎病毒感染者的血清进行检测,检测指标包括血清肿瘤相关抗原[癌胚抗原(CEA)、癌抗原125(CA125)、CA19-9、CA72-4]、肝纤四项[透明质酸钠(HA)、层粘连蛋白(LN)、Ⅳ型胶原(ⅣC)、Ⅲ型前胶原(PⅢNP)]及肝功能[总胆红素(TB)、直接胆红素(DB)、间接胆红素(IB)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)],并对结果进行统计学分析。结果CEA、CA125与HA、LN、ⅣC的血清指标分别有相关关系,且CA19-9与肝纤四项的相关关系有统计学意义。另外,CA19-9、CA125与TB、DB、IB、ALT也有相关关系。结论肿瘤相关抗原CEA、CA125、CA19-9检测常用于早期发现恶性肿瘤,对于慢性病毒性肝炎患者,这三项指标的升高可能不代表存在恶性肿瘤,而与慢性肝炎纤维化和炎症程度密切相关。
Objective To investigate the relationship between tumor-associated antigens of chronic viral hepatitis and liver fibrosis markers. Methods The serum of 51 patients with chronic hepatitis B virus infection was detected. The detection indexes included serum tumor-associated antigen (CEA, CA125, CA19-9, CA72-4) (HA, LN, IVC, PⅢNP) and liver function (total bilirubin (TB), direct bilirubin ), Indirect bilirubin (IB), alanine aminotransferase (ALT), aspartate aminotransferase (AST)], and the results were statistically analyzed. Results CEA, CA125 and HA, LN, IVC serum markers were correlated, and the correlation between CA19-9 and liver fibrosis four items was statistically significant. In addition, CA19-9, CA125 and TB, DB, IB, ALT are also related. Conclusion The detection of tumor-associated antigens CEA, CA125 and CA19-9 are commonly used in the early detection of malignant tumors. The elevated levels of these three indicators may not represent malignant tumors in patients with chronic viral hepatitis, but are closely related to the degree of inflammation and fibrosis of chronic hepatitis .