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目的:探讨在为患有AKI(急性肾损伤)合并症的SAP(重症急性胰腺炎)病例进行治疗时选择CRRT(连续性肾脏替代疗法)的疗效。方法:选择21例患有AKI合并症的SAP病例,对其进行疗法分组对照研究,将先接受治疗的10例划分为对照组,将后接受治疗的11例划分为观察组,选择的疗法分别为一般疗法、CRRT及一般疗法,监测在3天的治疗过程中病例体征指标的变化以及血浆细胞因子检测值的变化。结果:在3天的治疗过程中两组病例的体征指标和血浆细胞因子检测值均趋于正常水平,相较之下观察组的大部分体征指标(如BUN等)变化显著,大部分血浆细胞因子(如IL-1等)检测值下降明显(P<0.05)。结论:为患有AKI合并症的SAP病例实施CRRT,可以迅速控制病情,改善酸碱代谢状态,将代谢产生的废弃物和毒素排出体外,维持机体中细胞因子的正常水平,比一般疗法的疗效显著,可在SAP早期应用以避免发生AKI。
PURPOSE: To investigate the efficacy of CRRT (continuous renal replacement therapy) in the treatment of SAP (Severe Acute Pancreatitis) cases with AKI (acute kidney injury) comorbidities. Methods: Twenty-one SAP patients with AKI comorbidities were selected and divided into control group and control group. Ten patients were divided into control group and 11 patients were divided into observation group and selected therapy group For general therapies, CRRT and general therapies, changes in patient signs and changes in plasma cytokine measurements over the course of 3 days of treatment were monitored. Results: During the 3 days of treatment, the signs and the plasma cytokines in both groups tended to be normal. In contrast, most of the signs (such as BUN) in the observation group changed significantly. Most of the plasma cells Factors (such as IL-1, etc.) decreased significantly (P <0.05). CONCLUSIONS: CRRT is performed in SAP patients with AKI comorbid conditions to rapidly control the condition and improve the acid-base metabolic status. Excreted metabolites and toxins are excreted to maintain the normal level of cytokines in the body, which is more effective than the general therapy , Can be used early in SAP to avoid AKI.