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目的:探讨肝癌患者与正常健康人及化疗前后血小板4项参数的变化和临床意义。方法:用Sysmex,SE-9000全自动血液分析仪对正常健康人、肝癌患者及化疗前后血小板数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW)、大血小板比率(P-LCR)4项参数进行检测并比较。结果:肝癌患者PLT结果低于正常对照组,MPV结果高于正常对照组(P<0.05),差异有统计学意义。PDW、P-LCR结果明显高于正常对照组(P<0.01),差异有统计学意义。肝癌患者化疗后PLT、MPV、PDW、P-LCR结果均明显低于化疗前(P<0.01),差异有统计学意义。结论:血小板参数的检测可作为肝脏受损程度,肝癌疗效及预后判断的参考指标。
Objective: To investigate the changes and clinical significance of four parameters of platelets in patients with hepatocellular carcinoma before and after chemotherapy and normal controls. Methods: The levels of platelet count (PLT), platelet volume (MPV), platelet distribution width (PDW), and platelet ratio (P-LCR) in healthy and hepatocellular carcinoma patients before and after chemotherapy were measured by Sysmex and SE-9000 automatic blood analyzers. ) 4 parameters to detect and compare. Results: The results of PLT in patients with liver cancer were lower than those in normal controls, and the results of MPV were higher than those in normal controls (P <0.05). The difference was statistically significant. PDW, P-LCR results were significantly higher than the normal control group (P <0.01), the difference was statistically significant. The results of PLT, MPV, PDW and P-LCR in patients with hepatocellular carcinoma after chemotherapy were significantly lower than those before chemotherapy (P <0.01), the difference was statistically significant. Conclusion: The detection of platelet parameters can be used as a reference index of liver damage, efficacy and prognosis of liver cancer.