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目的探讨TORCH感染在新生儿、婴儿肝炎综合征发病中的作用。方法应用ELISA法对新生儿婴儿肝炎综合征97例患儿进行血清TORCH-IgM抗体测定。对CMV感染患儿除采用常规综合治疗外,加用更昔洛韦10 mg/(kg.d)静脉滴注,12 h/次,连用12~20 d。结果新生儿中21例、婴儿中16例患TORCH感染,均以巨细胞病毒感染为最多;母婴配对7例TORCH感染;对17例巨细胞病毒感染用更昔洛韦治疗,9例抗体转阴。结论TORCH感染是新生儿、婴儿肝炎综合征主要原因之一,TORCH感染引起临床表现多样化,更昔洛韦是治疗巨细胞病毒感染的有效药物。
Objective To explore the role of TORCH infection in the pathogenesis of neonatal and infant hepatitis syndrome. Methods Serum TORCH-IgM antibody was measured in 97 neonates with neonatal hepatitis syndrome by ELISA. CMV infection in children with conventional comprehensive treatment, plus ganciclovir 10 mg / (kg.d) intravenous infusion, 12 h / times, once every 12 to 20 d. Results 21 cases of newborn infants and 16 cases of TORCH infection in infants, were infected with cytomegalovirus most; maternal and child paired 7 cases of TORCH infection; 17 cases of cytomegalovirus infection with ganciclovir treatment, 9 cases of antibody turnover yin. Conclusion TORCH infection is one of the main causes of neonatal and infantile hepatitis syndrome. TORCH infection causes the diversification of clinical manifestations. Ganciclovir is an effective drug for the treatment of cytomegalovirus infection.