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用放射免疫法测定了８０例慢性肾脏病患者血浆皮质醇的变化。结果显示：无氮质血症的慢性肾小球疾病患者血浆皮质醇低于正常对照组（Ｐ＜０．００１），其浓度随肾功能的降低而增加。慢性肾脏病常并发感染、高血压等应激因素，使血浆皮质醇持续升高，从而可能是参与肾小球疾病进展至终末期肾衰的因素之一。
Plasma cortisol levels were measured in 80 patients with chronic kidney disease by radioimmunoassay. The results showed that plasma cortisol levels in patients with chronic glomerular disease without azotemia were lower than those in the normal control group (P <0.001), and their concentrations increased with decreasing renal function. Chronic kidney disease often complicated by infection, hypertension and other stress factors, so that continuous increase in plasma cortisol, which may be involved in the progression of glomerular disease to one of the factors of end-stage renal failure.