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目的 观察双黄连粉针剂治疗毛细支气管炎的临床疗效和安全性。方法 将 12 6例毛细支气管炎患儿随机分为两组 ,治疗组 6 4例 ,予双黄连 6 0mg·kg-1·d-1,对照组 6 2例 ,予病毒唑 10~ 15mg·kg-1·d-1,均稀释后静脉滴注 ,疗程 5~ 7d ,其余治疗两组相同。结果 治疗组治愈 4 2例 ,好转 2 1例 ,无效 1例 ;对照组治愈 2 4例 ,好转 32例 ,无效 6例 ,两组疗效比较差异有显著意义 (P <0 0 1)。治疗组发热、咳嗽、喘憋及肺部罗音消失天数均小于对照组 ,差异有显著意义 (P <0 0 1)。结论 双黄连粉针剂具有清热、抗菌、抗病毒作用 ,是治疗毛细支气管炎安全、有效的药物。
Objective To observe the clinical efficacy and safety of Shuanghuanglian injection in the treatment of bronchiolitis. Methods One hundred and sixty-six children with bronchiolitis were randomly divided into two groups: treatment group (64 cases), shuanghuanglian (60 mg · kg-1 · d-1) and control group (n = 62) -1 · d-1, were diluted intravenous infusion, treatment of 5 ~ 7d, the rest of the treatment of the same two groups. Results In the treatment group, 42 cases were cured, 21 cases improved, and 1 case was ineffective. In the control group, 24 cases were cured, 32 cases improved and 6 cases were ineffective. There was significant difference between the two groups (P <0.01). The treatment group fever, cough, wheezing and lung rales disappear days were less than the control group, the difference was significant (P <0.01). Conclusion Shuanghuanglian injection has the effects of heat-clearing, antibacterial and antiviral treatment and is a safe and effective drug for the treatment of bronchiolitis.