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目的 :探析血清脂联素(APN)、高敏C反应蛋白(hs-CRP)、内皮素1(ET-1)及一氧化氮(NO)在原发性高血压(PH)患者中的临床价值。方法 :分析2014年2月~2016年7月在我院接受诊治的98例PH患者的临床资料。另外选取我院同期接受健康体检的160例血压低于140/90mm Hg者作为本次研究的对照组,并根据血压水平的高低分成正常血压组(NBP组,低于120/80mm Hg,82例)和正常高值血压组(NHBP组,120~139/80~89mm Hg,78例)。比较三组患者的一般资料与血清APN、hs-CRP、ET-1及NO的表达水平,并相关性分析平均动脉压(MAP)、血清APN、hs-CRP、ET-1及NO,多因素Logistic回归分析PH患者MAP的影响因子。结果 :PH组患者的收缩压(SBP)、舒张压(DBP)及MAP水平显著较NBP组、NHBP组高,且NHBP组SBP、DBP及MAP水平又显著高于NBP组;三组患者其它一般资料(包括性别、年龄、BMI值等)无显著差异。PH组患者的血清hs-CRP、ET-1水平显著高于NBP组和NHBP组,而血清APN、NO水平则显著低于NBP组和NHBP组;与NBP组相比,NHBP组患者的血清APN及NP水平显著降低,血清hs-CRP与ET-1水平显著升高。血清APN、hs-CRP、ET-1、NO均是PH患者MAP的影响因子。结论 :PH患者体内血管舒缩及炎症因子平衡失调,主要表现为血清hs-CRP及ET-1水平上升,血清APN及NO水平降低,且这种失衡在NHBP患者中就已存在。
Objective: To investigate the clinical value of serum adiponectin (APN), high sensitivity C-reactive protein (hs-CRP), endothelin-1 (ET-1) and nitric oxide (NO) in patients with essential hypertension . Methods: Clinical data of 98 patients with PH who were treated in our hospital from February 2014 to July 2016 were analyzed. In addition, we selected 160 patients whose blood pressure was less than 140 / 90mm Hg at the same period of our hospital as the control group and divided them into normal blood pressure group (NBP group, lower than 120 / 80mm Hg, 82 cases ) And normal high blood pressure group (NHBP group, 120 ~ 139/80 ~ 89mm Hg, 78 cases). The levels of serum APN, hs-CRP, ET-1 and NO were compared between the three groups. The correlation analysis included mean arterial pressure, serum APN, hs-CRP, ET- Logistic Regression Analysis of Influencing Factors of MAP in PH Patients. Results: SBP, DBP and MAP in PH group were significantly higher than those in NBP group and NHBP group, and the levels of SBP, DBP and MAP in NHBP group were significantly higher than those in NBP group. The other three groups Data (including gender, age, BMI values, etc.) were not significantly different. The levels of serum hs-CRP and ET-1 in patients with PH were significantly higher than those in patients with NBP and NHBP, while the levels of serum APN and NO were significantly lower than those in patients with NBP and NHBP. Compared with patients in NBP, serum APN And NP levels were significantly decreased, serum hs-CRP and ET-1 levels were significantly increased. Serum APN, hs-CRP, ET-1 and NO were the influencing factors of MAP in PH patients. CONCLUSIONS: The imbalance of vasomotor and inflammatory cytokines in PH patients is mainly manifested by the increase of serum hs-CRP and ET-1 levels, and the decrease of serum APN and NO levels. This imbalance exists in patients with NHBP.