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目的探讨高血压人群中糖代谢异常的患病状况及其危险因素。方法 1166例原发性高血压(EH)患者完成血压、血糖、血脂、体脂参数测定,未确诊为T2DM者行OGTT。结果 (1)EH患者中T2DM的患病率23.33%,糖调节异常(IGR)患病率41.33%;(2)Logistic回归分析显示性别、饮酒、肥胖、T2DM家族史、高血压病程、收缩压、血脂与EH患者糖代谢异常的发生独立正相关。结论 (1)EH患者合并糖代谢异常(主要是餐后血糖升高)较常见,单纯检测FPG将漏诊60%的IGT患者和50%的单纯餐后高血糖患者;(2)EH患者若合并糖代谢异常,在空腹血糖受损阶段就应该关注;(3)男性、饮酒、腹型肥胖、EH家族史、T2DM家族史、EH病程长、高收缩压、高血脂是糖耐量正常EH患者发生糖代谢异常的独立危险因素。
Objective To investigate the prevalence and risk factors of abnormal glucose metabolism in hypertensive population. Methods A total of 1166 patients with essential hypertension (EH) were enrolled in the study of blood pressure, blood glucose, blood lipids and body fat parameters. OGTT was performed without diagnosis of T2DM. Results (1) The prevalence of T2DM in EH patients was 23.33%, the prevalence of abnormal glucose regulation (IGR) was 41.33%. (2) Logistic regression analysis showed that gender, alcohol consumption, obesity, family history of T2DM, duration of hypertension, systolic blood pressure , Blood fat and EH patients with abnormal glucose metabolism independent of the occurrence of an independent positive correlation. Conclusions (1) Patients with EH complicated by abnormal glucose metabolism (mainly postprandial hyperglycemia) are more common. Simple detection of FPG will miss 60% of IGT patients and 50% of patients with simple postprandial hyperglycemia; (2) (3) Male, alcohol consumption, abdominal obesity, family history of EH, family history of T2DM, long duration of EH, high systolic blood pressure, and hyperlipidemia are patients with normal glucose tolerance Independent risk factors for abnormal glucose metabolism.