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目的研究和分析胱抑素C、同型半胱氨酸以及内皮素的检测在早期糖尿病肾病中的临床意义。方法选择的研究对象是来我院就诊的186例糖尿病肾病患者,根据是否出现蛋白尿分为正常组和蛋白尿组。另外选择85例身体健康的人作为本次试验的对照组。患者入院后进行全面的检查,入院1 d后的清晨保证患者空腹抽取其适量静脉血,检测同型半胱氨酸,胱抑素C以及内皮素的水平,并进行对比分析。结果糖尿病肾病中正常组患者的胱抑素C,同型半胱氨酸水平分别为(15.12±12.3)μmol/L和(1.49±0.35)mg/L,与对照组和蛋白尿组相比差异有统计学意义(P>0.05)。正常组患者的Alb和内皮素水平分别为44.08±8.59 mg/24 h,61.76±11.58 pg/m L与对照组和蛋白质组患者数据相比差异有统计学意义(P<0.05)。结论同型半胱氨酸,胱抑素C以及内皮素水平对早期糖尿病肾病具有一定的诊断意义,对糖尿病患者肾功能改变有较为灵敏的反应,应用中方便可靠,值得临床推广使用。
Objective To study and analyze the clinical significance of detection of cystatin C, homocysteine and endothelin in early diabetic nephropathy. Methods The subjects of our study were 186 patients with diabetic nephropathy who were treated in our hospital and were divided into normal group and proteinuria group according to whether proteinuria occurred or not. In addition, 85 healthy individuals were selected as the control group for this study. Patients were admitted to hospital after a comprehensive examination, admission 1 d after the early morning to ensure that patients take appropriate amount of venous blood fasting, detection of homocysteine, cystatin C and endothelin levels, and comparative analysis. Results The levels of cystatin C and homocysteine in patients with diabetic nephropathy were (15.12 ± 12.3) μmol / L and (1.49 ± 0.35) mg / L, respectively, which were significantly lower than those in control group and proteinuria group Statistical significance (P> 0.05). The levels of Alb and endothelin in the normal group were 44.08 ± 8.59 mg / 24 h and 61.76 ± 11.58 pg / m L, respectively, which were significantly different from those in the control group and the proteomics group (P <0.05). Conclusions Homocysteine, cystatin C and endothelin levels have certain diagnostic value for early diabetic nephropathy. They are sensitive to changes of renal function in diabetic patients, and are convenient and reliable in application. They are worthy of clinical promotion.