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目的 :观察透明质酸在糖尿病肾病中的变化 ,探讨其临床意义。方法 :测定 30例健康对照者和 4 0例Ⅱ型糖尿病患者的透明质酸 (HA) ,糖化血红蛋白 (HbA1C) ,空腹血糖、脂质等指标。结果 :Ⅱ型糖尿病患者的血清HA水平显著高于正常对照组 (P <0 .0 1) ,伴有大量白蛋白尿的糖尿病患者的血清HA水平分别显著高于伴有微量白蛋白尿和正常白蛋白尿的患者。血清HA水平同HbA1C水平呈显著正相关 (r=0 .4 72 4 ,P <0 .0 5 ) ,同空腹血糖水平呈显著正相关 (r =0 .5 75 0 ,P <0 .0 1) ,同血胆固醇水平呈显著负相关 (r =- 0 .4 979,P <0 .0 5 )。结论 :Ⅱ型糖尿病患者血清HA水平与血糖控制有关 ,反映了糖尿病肾病的进展。
Objective: To observe the changes of hyaluronic acid in diabetic nephropathy and to explore its clinical significance. Methods: Hyaluronan (HA), HbA1C, fasting blood glucose and lipid were measured in 30 healthy controls and 40 type Ⅱ diabetic patients. Results: The level of serum HA in patients with type Ⅱ diabetes mellitus was significantly higher than that in controls (P <0.01). The serum levels of HA in diabetic patients with large albuminuria were significantly higher than those in patients with microalbuminuria and normal Patients with albuminuria. There was a significant positive correlation between serum HA level and HbA1C level (r = 0.7424, P <0.05), and positively correlated with fasting blood glucose level (r = 0.7575, P <0.01 ) Was negatively correlated with the level of blood cholesterol (r = - 0.4979, P <0.05). Conclusion: The level of serum HA in patients with type 2 diabetes is related to the control of blood glucose, reflecting the progress of diabetic nephropathy.