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针对当前钛种植体在临床使用中因界面不匹配导致的种植失败问题,从仿生学角度出发,采用提拉法在钛表面涂覆聚氨酯(PU)高分子涂层,并通过过饱和Ca-P溶液浸泡试验在PU表面原位矿化生成了无机沉积物。采用SEM、EDX、IR、XRD、DSC-TG及接触角测定仪等对矿化后PU表面的理化性能进行了表征和分析,并通过细胞培养试验初步考察了MG63细胞在矿化前后PU表面的增殖及生长情况。结果表明,PU表面矿化物是由纳米片状晶体先聚集堆叠形成团簇状微球,然后微球间互相融合生长而形成的,其成分主要是弱结晶的非化学计量的羟基磷灰石晶体,而且矿化后的PU涂层亲水性更佳,更利于MG63细胞的黏附及增殖。
Aiming at the problem of planting failure caused by the incompatibility of interface in clinical use of titanium implants, the surface of titanium is coated with polyurethane (PU) coating by the Czochralski method from bionics, and the supersaturated Ca-P In-solution mineralization resulted in the formation of inorganic deposits on PU surfaces. The physical and chemical properties of mineralized PU surface were characterized and analyzed by SEM, EDX, IR, XRD, DSC-TG and contact angle measuring instrument. The cell surface of MG63 Proliferation and growth. The results show that the surface mineralization of PU is formed by the first aggregation of nanosheet-like crystals to form clusters of microspheres, and then the microspheres are fused with each other. The composition of the surface is mainly composed of weakly crystalline non-stoichiometric hydroxyapatite crystals , And mineralized PU coating hydrophilic better, more conducive to MG63 cell adhesion and proliferation.