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为了解川崎病 (KD)患儿各期血脂变化并探讨其意义 ,前瞻性观察30例KD患儿急性期、亚急性期及恢复期血清甘油三酯 (TG)、胆固醇 (TC)、低密度脂蛋白 (LDL_C)及高密度脂蛋白 (HDL_C)的变化 ,并与30例同期患其他发热性疾病患儿的血脂四项参数比较 ,两组同期测定C_反应蛋白 (CRP)、红细胞沉降率 (ESR) ,并进行对比分析。结果显示 ,全部KD患儿均有脂质代谢异常 ,各期血清TG明显升高 ,而HDL_C明显降低 ,两者检测结果与对照组比较差异有极显著性 (P<0.001) ;亚急性期TC明显高于对照组 (P<0.05) ;各期LDL_C变化不大 ,与对照组比较差异无显著性 (P>0.05)。ESR、CRP两组比较差异无显著性 (P>0.05)。提示KD各期均存在血脂代谢异常 ,以急性期及亚急性期TG升高和HDL_C降低为著 ,血脂四项测定对KD的早期诊断及治疗具有指导意义
In order to understand the changes of blood lipids in children with KD and to explore its significance, 30 patients with KD were prospectively observed for serum triglyceride (TG), cholesterol (TC), low density (LDL_C) and high-density lipoprotein (HDL_C) in 30 children with other febrile disease.Meanwhile, the changes of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and comparative analysis. The results showed that all of the children with KD had dyslipidemia, serum TG significantly increased and HDL_C decreased significantly in both KD children. The results of the two tests were significantly different from those of the control group (P <0.001) (P <0.05). There was no significant difference in LDL_C between the two groups (P> 0.05). There was no significant difference between ESR and CRP (P> 0.05). It is suggested that dyslipidemia exists in all stages of KD, with the increase of TG and the decrease of HDL-C in acute and subacute phases, and the determination of four blood lipids is of guiding significance in the early diagnosis and treatment of KD