本研究说明急性肺炎患者中有1/3可以出现内毒素血症(ETM),并测得入院24小时血浆内毒素浓度,口服生大黄煎剂加抗生素治疗组低于抗生素对照组(P<0.05)。实验性肺炎球菌感染家兔 ETM 的阳性率为60%。感染后48小时内生大黄组的 ETM 阳性率及血浆内毒素浓度均低于水对照组(P<0.05)。肺炎Ⅲ号对急性惑染的 ETM 也有一定的影响。以上结果表明,急性感染中可以出现内源性的 ETM,应用大黄可以抑制并减轻 ETM 的发生。 This study showed that one-third of patients with acute pneumonia can have endotoxemia (ETM) and plasma endotoxin concentration is measured at admission for 24 hours, and oral rhubarb decoction plus antibiotic treatment group is lower than antibiotic control group (P<0.05). ). The positive rate of experimental pneumococcal infection in rabbit ETM was 60%. The ETM positive rate and plasma endotoxin concentration in the rhubarb group within 48 hours after infection were lower than those in the water control group (P<0.05). Pneumonia III also has an impact on acutely contaminated ETMs. The above results indicate that endogenous ETM can occur in acute infection and application of rhubarb can inhibit and reduce the occurrence of ETM.