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对单纯疱疹病毒(HSV)的原发感染、潜伏和复发之间的关系,曾作过广泛的研究。近三年来,关于病毒学、免疫学、组织化学和临床上的大量研究,足以证实HSV在组织中的传播方式,导致潜伏以及激活HSV而引起复发的假说。作者认为,临床或亚临床的原发感染,导致HSV潜伏和复发,可用对HSV的细胞免疫和抗体反应,以及被感染细胞表面上有病毒特异性抗原和Fc受体来解释。并可用以说明HSV和鳞状细胞癌之间的关系。
Extensive research has been conducted on the primary infection, latency and recurrence of herpes simplex virus (HSV). In the last three years, a great deal of virological, immunological, histochemical and clinical studies have proved sufficient to confirm the HSV transmission in tissues, resulting in the hypothesis of relapse caused by latency and activation of HSV. The authors suggest that clinical or subclinical primary infections lead to latent and recurrent HSV and may be explained by cellular immunity and antibody responses to HSV as well as viral-specific antigens and Fc receptors on the surface of infected cells. And can be used to illustrate the relationship between HSV and squamous cell carcinoma.