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目的 探讨血浆降钙素基因相关肽（ＣＧＲＰ）含量与糖尿病及其并发症之间的关系。方法 采用放射免疫分析法测定６７ 例非胰岛素依赖性糖尿病（ＮＩＤＤＭ）患者血浆ＣＧＲＰ水平的变化。结果 糖尿病无并发症患者血浆ＣＧＲＰ含量较对照组略有降低，但无显著性差异，伴有并发症各组明显低于对照组及无并发症组，随着伴有的并发症的增多，血浆ＣＧＲＰ水平也随之降低。结论 血浆ＣＧＲＰ水平的变化可能与糖尿病并发症的发展密切相关。
Objective To investigate the relationship between plasma calcitonin gene-related peptide (CGRP) and diabetes mellitus and its complications. Methods Radioimmunoassay was used to determine the plasma levels of CGRP in 67 patients with non-insulin dependent diabetes mellitus (NIDDM). Results There was no significant difference in plasma CGRP levels between patients with and without diabetes mellitus, but there was no significant difference between the two groups. Complications were significantly lower in each group than those in control group and non-complication group. With the increase of complication, plasma CGRP levels also decreased. Conclusion The change of plasma CGRP levels may be closely related to the development of diabetic complications.