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本工作用具有食道瘘的狗,观察假饲对糖耐量的影响并分析其机制。糖耐量测验的方法系由静脉注入40%葡萄糖溶液0.5克/千克体重。在注射前以及从注射葡萄糖时开始,每隔15、30、45、60、90及120分钟,分别由静脉取血,分析血糖浓度。假饲是在注射葡萄糖后立即开始的,假饲时间一般为14分钟。实验结果如下:(一)正常糖耐量曲线(不进行假饲)一般是相当恒定的。由静脉注射葡萄糖后15分钟,血糖浓度平均为165毫克%,并且一般在注射后60—90分钟内血糖浓度即恢复至注射前的水平。(二)当由静脉注射葡萄糖后立即进行假饲,结果使正常糖耐量显著增加,也就是使正常糖耐量曲线呈显著的减退性变化:血糖浓度在注射后的15分钟时,平均最高仅达138毫克%,并且在注射后45—60分钟内血糖浓度即恢复至原有水平。(三)当切断膈上的两侧迷走神经或切除胰腺的一切外来神经后,重复以上实验,结果假饲对糖耐量并无影响。因此,本工作更较明确地证明:假饲的进食动作确能唤起中枢神经系统的兴奋,通过迷走神经反射地引起胰岛素的分泌。
This work with esophageal fistula dogs to observe the impact of gummy feeding on glucose tolerance and analysis of its mechanism. The method of glucose tolerance test by intravenous injection of 40% glucose solution 0.5 g / kg body weight. Blood was taken from the venous blood and blood glucose levels were analyzed before injection and from the time of glucose injections, every 15, 30, 45, 60, 90 and 120 minutes. The dummy feeding begins immediately after the injection of glucose and the dummy feeding time is generally 14 minutes. The experimental results are as follows: (a) Normal glucose tolerance curve (without dummy feeding) is generally quite constant. Fifteen minutes after intravenous injection of glucose, the mean blood glucose concentration is 165 mg%, and the blood glucose concentration is generally returned to the pre-injection level within 60-90 minutes after injection. (B) when given intravenously immediately after glucose decontamination, resulting in a significant increase in normal glucose tolerance, that is, the normal glucose tolerance curve showed significant decrease in regression: blood glucose concentration at 15 minutes after injection, the average only up to 138 mg%, and within 45-60 minutes after injection blood glucose concentration that is restored to its original level. (C) After cutting off the vagus nerve on both sides of the diaphragm or resection of all the foreign nerves of the pancreas, repeat the above experiment, the results of gavage had no effect on impaired glucose tolerance. Therefore, this work more clearly shows that feeding action of feeding does indeed arouse the excitement of the central nervous system and cause the secretion of insulin through vagal reflex.