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目的观察重型β地中海贫血(TM)患者心脏房室扩大情况及其危险因素。方法对57例TM患者以心脏彩超测量其心脏房室大小,并记录一般情况、输血和去铁状况,测量血清铁蛋白浓度。结果 57例患者中19例有心房和(或)心室扩大。左心房、右心房、左心室、右心室扩大分别为14例(24.6%)、14例(24.6%)、10例(17.5%)、7例(12.3%)。相关分析表明,输血前血红蛋白浓度是影响心脏房室扩大的唯一独立因素。结论 TM患者中心脏房室改变较为普遍,需加强规范化输血治疗以维持输血前血红蛋白大于90 g/L。
Objective To observe the atrioventricular atrial enlargement and its risk factors in patients with severe β thalassemia (TM). Methods Fifty-seven patients with TM underwent cardiac echocardiography to measure the size of atrioventricular space. The general conditions, blood transfusion and iron removal were recorded, and serum ferritin concentration was measured. Results Of the 57 patients, 19 had atrial and / or ventricular enlargement. Left atrium, right atrium, left ventricle and right ventricular enlargement were 14 cases (24.6%), 14 cases (24.6%), 10 cases (17.5%) and 7 cases (12.3%). Correlation analysis showed that pre-transfusion hemoglobin concentration is the only independent factor affecting the atrioventricular enlargement. CONCLUSIONS: Atrioventricular changes are more common in patients with TM, and standardized blood transfusion therapy is needed to maintain hemoglobin greater than 90 g / L before transfusion.