我们参照药学通报1981年第8期上刊登的方法(28页),制备了磺胺嘧啶锌,配成混悬剂,以保留灌肠的方法用于慢性痢疾、结肠炎的治疗,一年多来,效果良好。但在以络合量法进行含量测定时,发现15批产品含量均在103%以上,多数在110%左右,个别高达243%,质量不稳定。分析原因可能是配制过程中生成部分氢氧化锌。为此,我们对制备工艺进行了改进。以氨水代替氢氧化钠,经过多次正交实验,找到一种节省原料、操作简单、收率高、质量稳定的制备方法。简介如下: We refer to the Bulletin of Pharmacology, 1981, No. 8, published in the method (28 pages), preparation of sulfadiazine zinc, dubbed suspension, retention enema for chronic dysentery, colitis treatment, more than a year, Good effect. However, in the determination of content by complexation method, it was found that the contents of 15 batches of products were above 103%, mostly around 110%, and the individual contents were as high as 243% with unstable quality. Analysis of the reasons may be part of the preparation process of generating zinc hydroxide. To this end, we have improved the preparation process. Ammonia instead of sodium hydroxide, after several orthogonal experiments, to find a save raw materials, simple operation, high yield, stable quality preparation. Brief introduction is as follows: