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目的:探讨太阳病(风寒表证)模型小鼠肺脏与大肠重量及系数的相关性变化。方法:180只小鼠随机分为对照组和模型组,造模成功后,分别在第7、10和14天随机从对照组和模型组随机抽取两组动物,称体质量后处死动物,取出肺和大肠,经处理后称重并计算肺脏和大肠脏器系数。结果:对照组和模型组肺脏脏器系数均有不同程度的下降,且模型组下降更为明显,其中第14天低于第7、10天(P<0.01,P<0.05);大肠重量及系数对照组均高于模型组,其中第7、10天大肠重量对照组明显高于模型组(P<0.01),第7天系数对照组明显高于模型组(P<0.01)。结论:风寒表证模型小鼠肺脏与大肠质量和系数变化较大,其病理变化有一定的相关性。
Objective: To investigate the correlation between the weight and coefficient of lung and large intestine in mouse model of solar disease (wind and cold syndrome). Methods: 180 mice were randomly divided into control group and model group. After the model was established, two groups of animals were randomly selected from the control group and the model group on the 7th, 10th, and 14th day respectively. After the animals were weighed, they were sacrificed and removed. The lungs and large intestines were weighed after treatment and lung and visceral organ coefficients were calculated. RESULTS: The lung organ coefficient of the control group and the model group all decreased to varying degrees, and the model group decreased more significantly. The 14th day was lower than the 7th and 10th days (P<0.01, P<0.05); the large intestine weight and The coefficients in the control group were all higher than those in the model group. The control group of the 7th and 10th day of the large intestine weight was significantly higher than that of the model group (P<0.01). The coefficient of the 7th day control group was significantly higher than that of the model group (P<0.01). Conclusion: The lungs and large intestine quality and coefficient of the model mice with cold-wind syndrome have great changes, and their pathological changes have a certain correlation.