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肾素-血管紧张素系统(RAS)参与动脉粥样硬化的发病过程,血管紧张素II(AngII)是诱发或加重动脉粥样硬化的重要因素。AT1(AngII)受体拮抗剂通过恢复和维持血管内皮功能,增强纤维蛋白溶解,防止低密度脂蛋白的氧化修饰等作用,在抗动脉粥样硬化进程中发挥重要作用,有着广阔的临床应用前景。
The renin-angiotensin system (RAS) is involved in the pathogenesis of atherosclerosis, and angiotensin II (AngII) is an important factor in inducing or worsening atherosclerosis. AT1 (AngII) receptor antagonists play an important role in anti-atherosclerotic process by restoring and maintaining vascular endothelial function, enhancing fibrinolysis, preventing the oxidative modification of LDL, and have a broad clinical application prospect .