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镁基金属以其良好的生物相容性、与骨组织匹配的力学性能以及在人体内可降解吸收等特点,成为极具临床应用前景的新型生物可降解植入材料,未来有望替代传统的医用金属材料(如不锈钢、钛合金等)应用于骨科内植入器件、心血管支架等领域。本文综合评述了近年来国内外可降解镁基金属的生物相容性研究进展,从合金化和表面改性2方面对镁基金属的体内外细胞相容性、血液相容性和组织相容性等相关研究进行了介绍,并对镁基金属未来在临床上的应用和发展趋势进行了展望。
Due to its good biocompatibility, mechanical properties matching with bone tissue and biodegradable absorption in human body, magnesium-based metal has become a new type of biodegradable implant material with clinical application prospect. It is expected to replace the traditional medical Metal materials (such as stainless steel, titanium, etc.) used in orthopedic implants, cardiovascular scaffolds and other fields. This review summarizes the recent advances in biocompatibility of biodegradable Mg-based metals both at home and abroad. The biocompatibility, biocompatibility and histocompatibility of Mg-based metals in vitro and in vivo are studied from the aspects of alloying and surface modification Sex and other related studies were introduced, and the future of magnesium-based metal in the clinical application and development trends are prospected.