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目的:比较欣母沛与米索前列醇预防巨大儿产后出血的临床疗效。方法:选择我院2008年1月至2011年12月收治存在产后出血高危因素并有剖宫产指征的巨大儿孕妇68例,随机分为观察组34例和对照组各34例,对照组于剖宫产术中胎儿娩出后即在子宫体部注射缩宫素20单位及口服米索前列醇0.4 mg,观察组给予宫壁注射缩宫素20单位及欣母沛250ug/ml,两组均予20单位缩宫素静脉维持。比较两组血压变化,产后2h内,24h内的出血量及不良反应率。结果:观察组产后2 h内及24 h内的出血量较对照组明显减少,不良反应率少,差异有统计学意义(P<0.05)。结论:应用欣母沛联合催产素应用预防巨大儿产后出血比米索前列醇效果更显著。“,”0bjective To compare the clinical efficacy of hemabate and misoprostol for preventing hemorrhage after cesarean section of women with fetal macrosomia .Methods 68 patients of cesarean section with fetal macrosomia were assigned to two groups,observation group(34 cases) and control group(34 cases).Control group was injected 20 units of oxytocin into their uterine corpus immediately after cesarean section and Oral 0.4 mg of Misoprostol. Observation group was injected 20 units of oxytocin and 250ug/ml Hemabate,then the two groups were all injected oxytocin by intravenous drip simultaneously.The bleeding amounts of 2 hours and 24 hours after operation were compared.The bleeding amounts of 2 hours and 24 hours in observation group were lower than the control group(P<0.05).Conclusion Hemabate joint oxytocin is more effective than misoprostol for preventing hemorhage after cesarean section of women with fetal macrosomia.