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目的:观察连续性血液净化(CBP)治疗对多器官功能障碍综合征(MODS)患者的治疗效果。方法:纳入本院30例MODS患者,对照组仅给予常规内科治疗,治疗组在常规治疗基础上联合连续性血液净化治疗,分别检测两组治疗前3d时0、2、6、12h血清中肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)、白介素-6(IL-6)、白介素-10(IL-10)浓度变化(ELISA法),并观察两组的器官功能恢复情况及血压、心率、呼吸等生命体征变化。结果:CBP治疗开始后血清IL-6、IL-10明显下降,6、12h时间点明显低于对照组,差异有统计学意义(P<0.01);CBP组各主要器官功能均明显改善,MAP基本保持在正常水平,尤其在6、12h时间点明显高于MODS组,差异有统计学意义(P<0.05)。PaO2逐渐升高,与MODS组在6、12h时间点比较差异有统计学意义(P<0.01)。结论:连续性血液净化能有效降低血清细胞因子IL-6、IL-10水平,改善MODS患者免疫功能,连续性血液净化可以成为MODS的有效救治措施。
Objective: To observe the therapeutic effect of continuous blood purification (CBP) on patients with multiple organ dysfunction syndrome (MODS). Methods: Thirty patients with MODS were enrolled in this study. Patients in the control group were given only conventional medical treatment. The patients in the treatment group were treated with continuous blood purification on the basis of conventional therapy. The serum levels of tumor in 0, 2, 6, The concentrations of TNF-α, IL-8, IL-6 and IL-10 were measured by enzyme linked immunosorbent assay (ELISA) Recovery and blood pressure, heart rate, respiratory and other vital signs. Results: Serum levels of IL-6 and IL-10 decreased significantly at the beginning of CBP treatment, and were significantly lower at 6 and 12 h (P <0.01). The function of all major organs in CBP group was significantly improved. MAP Basically maintained at the normal level, especially at 6, 12 h time points was significantly higher than MODS group, the difference was statistically significant (P <0.05). PaO2 gradually increased, compared with the MODS group at 6,12h point difference was statistically significant (P <0.01). CONCLUSION: Continuous blood purification can effectively reduce serum IL-6 and IL-10 levels and improve immune function in MODS patients. Continuous blood purification can be an effective treatment for MODS.