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采用溶液 -搅拌法制备奥沙普秦 -羟丙基 - β-环糊精包合物。用红外光谱、差示扫描量热分析等方法对包合物进行了鉴定和确证。含量测定证明包合物主、客分子比 1∶ 1。且奥沙普秦的溶解度由原来的 0 .0 18m g/ m l增至包合后的 2 .5 99mg/ ml
Oxaprozin-hydroxypropyl-β-cyclodextrin inclusion complex was prepared by solution-agitation method. The inclusion complex was identified and confirmed by IR, differential scanning calorimetry and other methods. Determination of the content of inclusion compound projectiles, off the ratio of 1: 1. And the solubility of oxaprozin increased from 0.018 m g / m l to 2.59 mg / ml after inclusion