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钙拮抗剂(Calcium antagonists)又称钙通道阻滞剂(Calcium channel blockers)是新近间世的一类心血管系药物的总称,其对心血管系统的共同特点在于都有负性肌力作用,有松弛血管或其它平滑肌而无β～受体阻滞作用,其中至少戊脉安尚可抑制窦房结并减慢房室传导。产生这些作用的基本机制在于它们能阻碍 Ca~(++)经细胞膜上的慢通道进入细胞内,从而减少细胞内 Ca~(++)的可用度,故而得名。
Calcium antagonists (Calcium channel blockers), also known as Calcium channel blockers, are a group of newly-emerged class of cardiovascular drugs. Their common feature in the cardiovascular system is that they all have negative inotropic effects, Relaxation of blood vessels or other smooth muscle without β ~ receptor blockade, of which at least verapamil can inhibit the sinus node and slow atrioventricular conduction. The basic mechanism behind these effects is that they can get their name by hindering Ca ~ (++) from entering the cell via slow channels in the cell membrane, thereby reducing the availability of intracellular Ca ~ (++).