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目的了解完成基础免疫的学龄前儿童乙肝病毒表面抗体(抗-HBs)的阳性率及免疫效果。方法对所有监测儿童采集静脉血3 ml,采用酶联免疫法检测抗乙肝病毒表面抗体(抗-HBs)。结果 342名儿童中抗-HBs阳性277人,阳性率为80.99%,不同年龄组间阳转率差异有统计学意义,男女间差异有统计学意义。结论学龄前儿童在完成初次乙肝疫苗全程接种后抗-HBs阳性率有所下降,应定期对该群体进行抗-HBs检测并及时对乙肝疫苗无(低)应答者给予加强免疫,以提高儿童对乙肝病毒的免疫水平,确保有效预防乙肝的传播。
Objective To understand the positive rate and immune effect of hepatitis B virus surface antibody (anti-HBs) in preschool children who have completed basic immunization. Methods Blood was collected from 3 ml of all monitored children and tested for anti-hepatitis B virus surface antibodies (anti-HBs) by enzyme-linked immunosorbent assay. Results The positive rate of anti-HBs in 342 children was 277, with a positive rate of 80.99%. There was significant difference in the positive conversion rate among different age groups. The difference between male and female was statistically significant. Conclusions The positive rate of anti-HBs in pre-school children after completion of the initial vaccination of hepatitis B vaccine is reduced. Anti-HBs test should be conducted on this group regularly and the immune response to no (low) Hepatitis B virus immune levels, to ensure effective prevention of hepatitis B transmission.