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目的研究幽门弯曲菌（Ｈｐ）Ｓ１型ＶａｃＡ基因与胃十二指肠疾病的关系。方法用ＰＣＲ技术检测６０株Ｈｐ的Ｓ１型ＶａｃＡ基因。６０株Ｈｐ分别分离自８例胃癌、１９例消化性溃疡和３３例慢性胃炎患者。结果７例胃癌、１５例消化性溃疡和３例慢性胃炎患者的Ｈｐ检出Ｓ１型ＶａｃＡ基因，检出率分别为８７．５％，７８．９％和９．１％。结论感染含Ｓ１型ＶａｃＡ基因的Ｈｐ与消化性溃疡的发生有密切的关系，可能与胃癌的发生有关。
Objective To study the relationship between VacA gene of Campylobacter pylori (Hp) type S1 and gastroduodenal diseases. Methods Sixty strains of Hp VacA gene of type S1 were detected by PCR. Sixty isolates of Hp were isolated from 8 patients with gastric cancer, 19 patients with peptic ulcer and 33 patients with chronic gastritis. Results The HspV gene of S1 was detected in 7 cases of gastric cancer, 15 cases of peptic ulcer and 3 cases of chronic gastritis. The positive rates of VacA gene were 87.5%, 78.9% and 9.1% respectively. Conclusion The infection of Hp with S1 VacA gene is closely related to the occurrence of peptic ulcer and may be related to the occurrence of gastric cancer.