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骨桥蛋白(osteopontin,OPN)是一种磷酸化酸性糖蛋白分子,人体的破骨细胞、巨噬细胞、T细胞、以及血管平滑肌细胞等均可分泌OPN,其基因定位于染色体4q13。OPN具有细胞黏连蛋白的功能,可以与CD44、整合素αvβ3以及αvβ5结合,OPN还参与骨质重建、新血管生成和炎症反应;OPN在肿瘤转移中起协同作用。在卵巢癌的早期诊断和预后监测方面可作为CA125以及其他细胞因子等标志物的补充。检测方法可望更简便。在基因转录水平上抑制OPN及其主要受体可能成为治疗肿瘤的新药物靶点。
Osteopontin (OPN) is a phosphorylated acidic glycoprotein. OPN is secreted by human osteoclasts, macrophages, T cells and vascular smooth muscle cells, and its gene is located on chromosome 4q13. OPN has the function of cell adhesion protein and can bind to CD44, integrin αvβ3 and αvβ5. OPN is also involved in bone remodeling, neovascularization and inflammation; OPN plays a synergistic role in tumor metastasis. In the early diagnosis and prognosis of ovarian cancer can be used as CA125 and other cytokines and other markers in addition. Detection method is expected to be more simple. Inhibition of OPN and its major receptor at the gene transcriptional level may become a new drug target for the treatment of tumors.