目的 :合成二钠 3 -氨基 -1 -羟基 -亚丙基 -二膦酸盐 (帕米膦酸二钠 )。方法 :有、无溶剂的两种合成路线 ,并对工艺进行改进。所得产物经元素分析 ,红外光谱 ,质谱等分析确证结构。结果 :两种路线均可合成目标化合物。路线A收率高于路线B。结论 :溶剂的加入使本反应体系均一 ,有利于产物生成 AIM: To synthesize disodium 3 - amino - 1 - hydroxy - propylidene - diphosphonate (pamidronate disodium). Methods: There are two synthetic routes without solvent and the process is improved. The resulting product was confirmed by elemental analysis, infrared spectroscopy, mass spectrometry and other structures. Results: The target compounds can be synthesized in both routes. Route A yield is higher than Route B. Conclusion: The addition of solvent to make the reaction system uniform, is conducive to product formation